Pure MDMA

Product Description

3,4-Methylenedioxymethamphetamine (MDMA) is an entactogen belonging to the substituted phenethylamine and substituted amphetamine chemical classes. Formulated as a high-purity crystalline hydrochloride salt, it serves as a calibrated analytical reference material for academic pharmacology, forensic toxicology, and controlled clinical investigational assays. It provides baseline profiling for chromatographic resolution, quantitative peak integration, and chemical degradation studies under laboratory conditions.

Chemical & Pharmacodynamic Properties

• Chemical Formula & Molecular Mass: $\text{C}_{11}\text{H}_{15}\text{NO}_2 \cdot \text{HCl}$ | 229.70 g/mol (HCl salt)

• Mechanism of Action: Functions primarily as a potent monoamine-releasing agent with selective substrate activity at presynaptic reuptake transporters. It binds to and reverses the vesicular monoamine transporter 2 ($\text{VMAT}_2$) and plasma membrane monoamine transporters—predominantly the serotonin transporter ($\text{SERT}$), followed by the norepinephrine transporter ($\text{NET}$) and dopamine transporter ($\text{DAT}$)—triggering massive exocytotic-independent monoamine efflux.

• Secondary Receptor Interactions: Displays direct binding affinity as a partial agonist at central $5\text{-HT}_{2\text{A}}$, $5\text{-HT}_{2\text{B}}$, and $5\text{-HT}_{2\text{C}}$ receptors, trace amine-associated receptor 1 ($\text{TAAR}_1$), and modulates peripheral neuroendocrine release, including oxytocin and arginine vasopressin.

• Presumptive Reagent Verification: Utilized to calibrate diagnostic cross-reactivity and validate presumptive colorimetric spot-test profiles with Marquis (deep purple-black), Simon’s (bright blue), Mecke (green to dark blue), and Mandelin reagents.

Toxicological Profile & Regulatory Status

• Strict Laboratory Application: Synthesized and distributed strictly for authorized research institutions, diagnostic forensic laboratories, and accredited reference facilities.

• Toxicological & Systemic Risks: Inadvertent in vivo exposure presents serious physiological and toxicological risks, including severe sympathomimetic toxicity (malignant hyperthermia, marked tachycardia, malignant hypertension), serotonin syndrome, acute dilutional hyponatremia due to inappropriate antidiuretic hormone secretion, rhabdomyolysis, and acute multiorgan failure. Chronic exposure can cause sustained down-regulation of serotonin axons and terminals.

• Controlled Substance Classification: MDMA is strictly controlled under federal and international statutes, designated as a Schedule I controlled substance under the United States Controlled Substances Act, a Class A drug in the United Kingdom, and listed under Schedule I of the UN 1971 Convention on Psychotropic Substances. Handling, storage, and procurement require certified institutional licensing and DEA registration.