100ML 4–ACO-DMT Microdosing Kit online

Product Beschrijving

4-AcO-DMT (4-acetoxy-$N,N$-dimethyltryptamine), commonly designated as psilacetin or $O$-acetylpsilocin, is a semi-synthetic indole alkaloid within the substituted tryptamine chemical family. Structurally related to the fungal alkaloids psilocybin and psilocin, 4-AcO-DMT serves as a vital analytical benchmark in forensic toxicology, synthetic drug screening, and neuropharmacological research aimed at understanding tryptamine ester stability, metabolic pathways, and monoaminergic signaling.

Chemical & Pharmacodynamic Properties

• Molecular Formula & Mass: $\text{C}_{14}\text{H}_{18}\text{N}_2\text{O}_2$ | 246.31 g/mol (free base)

• Chemical Structure: Composed of an indole core substituted with an acetoxy group at the 4-position and an ethylamine side chain bearing two terminal methyl groups at the nitrogen atom.

• Prodrug Kinetics & Hydrolysis: Chemically acts as an acetylated ester analog of psilocin (4-OH-DMT). In biological systems, it undergoes rapid deacetylation via endogenous esterases (such as non-specific carboxylesterases) into active psilocin. In aqueous or polar volumetric solutions, exposure to light, moisture, or elevated pH can accelerate spontaneous ambient hydrolysis and subsequent quinone oxidation, making stability testing a core focus in laboratory workflows.

• Receptor Affinity: Following enzymatic deacetylation, the active metabolite functions as a partial agonist with high binding affinity at central serotonin $5\text{-HT}_{2\text{A}}$, $5\text{-HT}_{2\text{C}}$, En $5\text{-HT}_{1\text{A}}$ receptors, inducing downstream modulation of cortical glutamatergic signaling.

Analytical Applications & Forensic Profiling

• Volumetric Reference Stability: Utilized in controlled dilution experiments to determine rate constants of hydrolytic degradation across various temperature, solvent, and pH gradients.

• Instrumental Calibration: Provides reference retention parameters and mass spectral fragmentation patterns for Liquid Chromatography-Tandem Mass Spectrometry ($\text{LC-MS/MS}$) and High-Performance Liquid Chromatography with Photodiode Array Detection ($\text{HPLC-PDA}$).

• Presumptive Colorimetric Screening: Serves as a reference analyte to evaluate and document colorimetric reactivity thresholds using Ehrlich’s reagent (yielding a characteristic purple/violet transition indicative of an intact indole nucleus) and Marquis reagent.

Toxicological Profile & Regulatory Oversight

• In Vitro & Forensic Restriction: Synthesized, handled, and distributed exclusively for accredited forensic laboratories, chemical research facilities, and licensed educational institutions.

• Toxicological Hazards: Inadvertent systemic exposure in humans presents acute clinical risks, including autonomic activation (marked pupillary dilation, tachycardia, mild arterial hypertension), hyperreflexia, profound sensory distortion, impaired motor coordination, and severe, unpredictable neuropsychiatric anxiety or panic states. Systematic long-term human clinical safety and toxicology data remain limited.

• Regulatory & Controlled Substance Status: While not explicitly listed on federal statutory schedules in every jurisdiction, 4-AcO-DMT is subject to controlled substance enforcement under analogue laws (such as the Federal Analogue Act in the United States, as a positional isomer or chemical analog of psilocin/psilocybin), and is specifically scheduled under psychotropic control statutes in several other nations (e.g., Class A in the United Kingdom). Handling and acquisition require compliance with institutional toxic substance safety guidelines and applicable statutory research permits.