{"id":10608,"date":"2026-09-16T09:09:48","date_gmt":"2026-09-16T09:09:48","guid":{"rendered":"https:\/\/europepharmacy.eu\/?post_type=product&#038;p=10608"},"modified":"2026-09-16T09:10:24","modified_gmt":"2026-09-16T09:10:24","slug":"oxycontin-40mg-2","status":"publish","type":"product","link":"https:\/\/europepharmacy.eu\/nl\/shop\/oxycontin-40mg-2\/","title":{"rendered":"OxyContin 40mg"},"content":{"rendered":"<p data-path-to-node=\"5\">OxyContin 40 mg oral tablets deliver a high-potency, semi-synthetic <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"69\">$\\mu$<\/span>-opioid agonist via an advanced extended-release (ER) delivery system. Indicated strictly for severe, chronic, around-the-clock pain profiles, this formulation allows for a 12-hour dosing interval by continuously releasing oxycodone to maintain stable therapeutic plasma levels, reducing the peak-and-trough fluctuations common with immediate-release opioids.<\/p>\n<p data-path-to-node=\"6\"><b data-path-to-node=\"6\" data-index-in-node=\"0\">Clinical Profile &amp; Physical Identification<\/b><\/p>\n<ul data-path-to-node=\"7\">\n<li>\n<p data-path-to-node=\"7,0,0\"><b data-path-to-node=\"7,0,0\" data-index-in-node=\"0\">Active Ingredient:<\/b> Oxycodone Hydrochloride (40 mg)<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"7,1,0\"><b data-path-to-node=\"7,1,0\" data-index-in-node=\"0\">Appearance &amp; Imprint:<\/b> Yellow, round, bi-convex tablet debossed with &#8220;OP&#8221; on one side and &#8220;40&#8221; on the reverse.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"7,2,0\"><b data-path-to-node=\"7,2,0\" data-index-in-node=\"0\">Abuse-Deterrent Formulation:<\/b> Manufactured using a specialized physicochemical polymer matrix designed to resist physical manipulation (crushing, grinding, or chewing) and chemical extraction. If exposed to aqueous solvents, the tablet forms a viscous hydrogel that resists syringe injection.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"7,3,0\"><b data-path-to-node=\"7,3,0\" data-index-in-node=\"0\">Farmacokinetiek:<\/b> Exhibits a biphasic absorption profile, providing an initial release of medication followed by a prolonged, steady release over 12 hours. Extensively metabolized in the liver via CYP3A4 and CYP2D6 enzymes.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"8\"><b data-path-to-node=\"8\" data-index-in-node=\"0\">Indications &amp; Clinical Administration<\/b><\/p>\n<ul data-path-to-node=\"9\">\n<li>\n<p data-path-to-node=\"9,0,0\"><b data-path-to-node=\"9,0,0\" data-index-in-node=\"0\">Around-the-Clock Analgesia:<\/b> Indicated for severe pain requiring continuous, long-term opioid therapy where non-opioid analgesics or immediate-release opioids are ineffective, not tolerated, or would be otherwise inadequate.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"9,1,0\"><b data-path-to-node=\"9,1,0\" data-index-in-node=\"0\">Strict Administration Protocol:<\/b> Tablets MUST be swallowed whole with enough water to ensure complete swallowing immediately after placing in the mouth. Crushing, chewing, breaking, or dissolving the tablet defeats the extended-release mechanism, leading to rapid systemic absorption of a potentially fatal dose of oxycodone.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"10\"><b data-path-to-node=\"10\" data-index-in-node=\"0\">Important Safety Information &amp; Boxed Warnings<\/b><\/p>\n<ul data-path-to-node=\"11\">\n<li>\n<p data-path-to-node=\"11,0,0\"><b data-path-to-node=\"11,0,0\" data-index-in-node=\"0\">Addiction, Abuse, and Misuse:<\/b> As a Schedule II controlled substance, OxyContin exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death.<\/p>\n<\/li>\n<li>\n<p id=\"p-rc_9dc128139ad04c65-76\" data-path-to-node=\"11,1,0\"><b data-path-to-node=\"11,1,0\" data-index-in-node=\"0\">Life-Threatening Respiratory Depression:<\/b> Serious, life-threatening, or fatal respiratory depression may occur. Peak risk occurs during initiation of therapy or following a do<span class=\"citation-219 citation-end-219\">se increase.<\/span><\/p>\n<\/li>\n<li>\n<p id=\"p-rc_9dc128139ad04c65-77\" data-path-to-node=\"11,2,0\"><b data-path-to-node=\"11,2,0\" data-index-in-node=\"0\"><span class=\"citation-218\">Accidental Ingestion:<\/span><\/b><span class=\"citation-218 citation-end-218\"> Accidental ingestion of even one dose of OxyContin, especially by children, can result in a fatal overdose of oxycodone.<\/span><\/p>\n<\/li>\n<li>\n<p id=\"p-rc_9dc128139ad04c65-78\" data-path-to-node=\"11,3,0\"><b data-path-to-node=\"11,3,0\" data-index-in-node=\"0\"><span class=\"citation-217 citation-end-217\">Risks from Concomitant Use with Benzodiazepines &amp; CNS Depres<\/span>sants:<\/b> Co-administration with benzodiazepines, alcohol, or other central nervous system depressants significantly increases the risk of profound sedation, respiratory depression, coma, and death.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"11,4,0\"><b data-path-to-node=\"11,4,0\" data-index-in-node=\"0\">Cytochrome P450 3A4 Interaction:<\/b> Concomitant use with CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers) can result in a fatal increase in oxycodone plasma concentrations.<\/p>\n<\/li>\n<\/ul>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>OxyContin 40 mg (oxycodone hydrochloride extended-release) is a Schedule II prescription opioid agonist indicated for the management of severe pain requiring daily, around-the-clock, long-term opioid treatment when alternative options are inadequate. Manufactured as a yellow, round tablet with abuse-deterrent properties (imprinted with &#8220;OP&#8221; and &#8220;40&#8221;), it utilizes a controlled-release polymer matrix to provide continuous 12-hour analgesia. Dispensed strictly by valid prescription under physician supervision.<\/p>","protected":false},"featured_media":10610,"comment_status":"open","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108,107],"product_tag":[924,923,894,927,922,921,262,926,866,925],"class_list":["post-10608","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_cat-painkillers","product_tag-abuse-deterrent-formulation","product_tag-around-the-clock-pain-management","product_tag-c-ii-medication","product_tag-long-acting-painkiller","product_tag-op-40-yellow-pill","product_tag-oxycodone-extended-release","product_tag-oxycontin-40mg","product_tag-rx-only-analgesic","product_tag-schedule-ii-opioid","product_tag-severe-chronic-pain","instock","sale","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>OxyContin 40mg<\/title>\n<meta name=\"description\" content=\"OxyContin 40 mg (oxycodone hydrochloride extended-release) is a Schedule II prescription opioid agonist indicated for the management of severe pain requiring daily, around-the-clock, long-term opioid treatment when alternative options are inadequate. 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Manufactured as a yellow, round tablet with abuse-deterrent properties (imprinted with &quot;OP&quot; and &quot;40&quot;), it utilizes a controlled-release polymer matrix to provide continuous 12-hour analgesia. 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