{"id":10951,"date":"2026-09-21T17:18:13","date_gmt":"2026-09-21T17:18:13","guid":{"rendered":"https:\/\/europepharmacy.eu\/?post_type=product&#038;p=10951"},"modified":"2026-09-21T17:22:55","modified_gmt":"2026-09-21T17:22:55","slug":"10951","status":"publish","type":"product","link":"https:\/\/europepharmacy.eu\/it\/shop\/10951\/","title":{"rendered":"Pure Colombian Cocaine \u2744\ufe0f\u26c4\ufe0f 100% RAW UNCUT"},"content":{"rendered":"<p data-path-to-node=\"11\">Cocaine (benzoylmethylecgonine) is a naturally occurring tropane alkaloid extracted from the leaves of the coca plant (<i data-path-to-node=\"11\" data-index-in-node=\"119\">Erythroxylum coca<\/i> and <i data-path-to-node=\"11\" data-index-in-node=\"141\">Erythroxylum novogranatense<\/i>). While historically approved in limited medical contexts as a topical local anesthetic for mucous membranes of the ear, nose, and throat, the overwhelming majority of forensic casework involves clandestine cocaine hydrochloride or freebase (&#8220;crack&#8221;) matrices. Clandestine marketing designations such as &#8220;100% Raw Uncut&#8221; or &#8220;Colombian Pure&#8221; contrast sharply with forensic seizure data from agencies such as the DEA and EMCDDA, which consistently identify production-level adulteration and residual chemical processing markers even in wholesale-tier seizures.<\/p>\n<p data-path-to-node=\"12\"><b data-path-to-node=\"12\" data-index-in-node=\"0\">Chemical &amp; Physical Profile<\/b><\/p>\n<ul data-path-to-node=\"13\">\n<li>\n<p data-path-to-node=\"13,0,0\"><b data-path-to-node=\"13,0,0\" data-index-in-node=\"0\">Active Analyte:<\/b> Cocaine hydrochloride (<span class=\"math-inline\" data-math=\"\\text{C}_{17}\\text{H}_{21}\\text{NO}_4 \\cdot \\text{HCl}\" data-index-in-node=\"39\">$\\text{C}_{17}\\text{H}_{21}\\text{NO}_4 \\cdot \\text{HCl}$<\/span>).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"13,1,0\"><b data-path-to-node=\"13,1,0\" data-index-in-node=\"0\">IUPAC Nomenclature:<\/b> Methyl <span class=\"math-inline\" data-math=\"(1R,2R,3S,5S)\\text{-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate hydrochloride}\" data-index-in-node=\"27\">$(1R,2R,3S,5S)\\text{-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate hydrochloride}$<\/span>.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"13,2,0\"><b data-path-to-node=\"13,2,0\" data-index-in-node=\"0\">Molecular Weight:<\/b> 303.35 g\/mol (freebase) | 339.81 g\/mol (hydrochloride salt).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"13,3,0\"><b data-path-to-node=\"13,3,0\" data-index-in-node=\"0\">Physical Presentation:<\/b> White to off-white crystalline flakes, dense compressed powder (&#8220;flake&#8221; or &#8220;fish-scale&#8221; sheen, often an optical effect of crystalline compaction or adulteration with boric acid), soluble in water, ethanol, and chloroform; insoluble in diethyl ether.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"14\"><b data-path-to-node=\"14\" data-index-in-node=\"0\">Clandestine Processing, &#8220;Purity&#8221; Reality, &amp; Adulteration Dynamics<\/b><\/p>\n<ul data-path-to-node=\"15\">\n<li>\n<p data-path-to-node=\"15,0,0\"><b data-path-to-node=\"15,0,0\" data-index-in-node=\"0\">Wholesale vs. Retail Purity:<\/b> Forensic analyses of seized wholesale kilogram &#8220;bricks&#8221; originating from Colombian processing laboratories typically display active cocaine purities ranging between 65% and 85%, rather than absolute chemical purity.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"15,1,0\"><b data-path-to-node=\"15,1,0\" data-index-in-node=\"0\">Secondary Alkaloids &amp; Processing Markers:<\/b> Unrefined natural alkaloid markers routinely identified in origin profiling include:<\/p>\n<ul data-path-to-node=\"15,1,1\">\n<li>\n<p data-path-to-node=\"15,1,1,0,0\"><i data-path-to-node=\"15,1,1,0,0\" data-index-in-node=\"0\">cis-<\/i> and *trans-*cinnamoylcocaine.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"15,1,1,1,0\">Tropacocaine and hygrine.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"15,1,1,2,0\">Ecgonine methyl ester and benzoylecgonine (hydrolysis breakdown products).<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"15,2,0\"><b data-path-to-node=\"15,2,0\" data-index-in-node=\"0\">Source-Level Adulteration (Cutting Agents):<\/b> Modern illicit cocaine exhibits are frequently adulterated at the chemical processing stage in South America prior to international export:<\/p>\n<ul data-path-to-node=\"15,2,1\">\n<li>\n<p data-path-to-node=\"15,2,1,0,0\"><b data-path-to-node=\"15,2,1,0,0\" data-index-in-node=\"0\">Levamisole:<\/b> A veterinary anthelmintic agent added in up to 70% of seized exhibits. It potentiates dopaminergic transmission via its metabolite, aminorex, and increases bulk yield while passing standard melting-point or density checks.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"15,2,1,1,0\"><b data-path-to-node=\"15,2,1,1,0\" data-index-in-node=\"0\">Phenacetin:<\/b> An analgesic withdrawn from clinical markets due to nephrotoxicity and carcinogenicity, frequently added due to its physical crystalline resemblance to cocaine flake.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"15,2,1,2,0\"><b data-path-to-node=\"15,2,1,2,0\" data-index-in-node=\"0\">Local Anesthetics:<\/b> Benzocaine, lidocaine, and procaine, introduced to mimic the rapid peripheral numbing sensation of cocaine on mucous membranes.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"16\"><b data-path-to-node=\"16\" data-index-in-node=\"0\">Pharmacodynamics &amp; Mechanisms of Action<\/b><\/p>\n<ul data-path-to-node=\"17\">\n<li>\n<p data-path-to-node=\"17,0,0\"><b data-path-to-node=\"17,0,0\" data-index-in-node=\"0\">Triple Monoamine Reuptake Inhibition:<\/b> Cocaine functions as a competitive, non-substrate blocker of plasma membrane monoamine transporters:<\/p>\n<ul data-path-to-node=\"17,0,1\">\n<li>\n<p data-path-to-node=\"17,0,1,0,0\"><b data-path-to-node=\"17,0,1,0,0\" data-index-in-node=\"0\">Dopamine Transporter (DAT):<\/b> Blocks the dopamine reuptake transporter in the mesolimbic and mesocortical pathways, causing rapid synaptic dopamine accumulation that mediates acute euphoria and high addiction liability.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"17,0,1,1,0\"><b data-path-to-node=\"17,0,1,1,0\" data-index-in-node=\"0\">Norepinephrine Transporter (NET):<\/b> Potently blocks norepinephrine clearance, precipitating intense peripheral and central sympathomimetic tone.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"17,0,1,2,0\"><b data-path-to-node=\"17,0,1,2,0\" data-index-in-node=\"0\">Serotonin Transporter (SERT):<\/b> Moderately inhibits serotonin reuptake, contributing to mood alterations and central cardiovascular regulation.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"17,1,0\"><b data-path-to-node=\"17,1,0\" data-index-in-node=\"0\">Voltage-Gated Sodium Channel (<span class=\"math-inline\" data-math=\"Na_v\" data-index-in-node=\"30\">$Na_v$<\/span>) Blockade:<\/b> Acts as a Class I local anesthetic by reversibly binding to the inner pore of voltage-gated sodium channels in neuronal axons and cardiac myocytes. This prevents inward sodium current (<span class=\"math-inline\" data-math=\"I_{Na}\" data-index-in-node=\"231\">$I_{Na}$<\/span>), arresting the initiation and propagation of action potentials.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"18\"><b data-path-to-node=\"18\" data-index-in-node=\"0\">Toxicology &amp; Acute Clinical Hazards<\/b><\/p>\n<ul data-path-to-node=\"19\">\n<li>\n<p data-path-to-node=\"19,0,0\"><b data-path-to-node=\"19,0,0\" data-index-in-node=\"0\">Acute Cardiotoxicity:<\/b> The combination of intense sympathomimetic stimulation (elevated heart rate and blood pressure via NET blockade) and cardiac sodium channel inhibition can cause acute myocardial ischemia, coronary vasospasm, ventricular tachycardia, QRS widening, and sudden fatal cardiac arrest.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"19,1,0\"><b data-path-to-node=\"19,1,0\" data-index-in-node=\"0\">Levamisole-Induced Syndromes:<\/b> Chronic exposure to levamisole-adulterated cocaine triggers severe immunological pathology:<\/p>\n<ul data-path-to-node=\"19,1,1\">\n<li>\n<p data-path-to-node=\"19,1,1,0,0\"><b data-path-to-node=\"19,1,1,0,0\" data-index-in-node=\"0\">Agranulocytosis:<\/b> Profound neutropenia rendering individuals susceptible to life-threatening opportunistic bacterial and fungal infections.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"19,1,1,1,0\"><b data-path-to-node=\"19,1,1,1,0\" data-index-in-node=\"0\">Levamisole-Induced Vasculitis:<\/b> Retiform purpura manifesting as painful, necrotic skin lesions typically affecting the earlobes, extremities, and cheeks, often accompanied by crescentic glomerulonephritis.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"19,2,0\"><b data-path-to-node=\"19,2,0\" data-index-in-node=\"0\">Neurological &amp; Hyperthermic Complications:<\/b> Excessive dopaminergic and adrenergic signaling can trigger grand mal seizures, intracerebral hemorrhage, stroke, acute toxic delirium, and malignant hyperthermia leading to rhabdomyolysis and renal failure.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"20\"><b data-path-to-node=\"20\" data-index-in-node=\"0\">Analytical Screening &amp; Forensic Identification<\/b><\/p>\n<ul data-path-to-node=\"21\">\n<li>\n<p data-path-to-node=\"21,0,0\"><b data-path-to-node=\"21,0,0\" data-index-in-node=\"0\">Presumptive Colorimetric Screening:<\/b><\/p>\n<ul data-path-to-node=\"21,0,1\">\n<li>\n<p data-path-to-node=\"21,0,1,0,0\"><b data-path-to-node=\"21,0,1,0,0\" data-index-in-node=\"0\">Scott\u2019s Reagent (Cobalt Thiocyanate):<\/b> The benchmark presumptive field test. Addition of cocaine hydrochloride to the reagent yields an immediate bright blue precipitate. Addition of concentrated hydrochloric acid dissolves the precipitate into a clear pink solution. Addition of chloroform extracts the blue chromophore into the lower organic layer, confirming a presumptive positive.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"21,0,1,1,0\"><b data-path-to-node=\"21,0,1,1,0\" data-index-in-node=\"0\">Liebermann Reagent:<\/b> Typically yields a yellow-to-orange\/brown transition (often influenced by cutting agents like levamisole or phenacetin).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"21,0,1,2,0\"><b data-path-to-node=\"21,0,1,2,0\" data-index-in-node=\"0\">Marquis Reagent:<\/b> Unreactive (remains clear) with pure cocaine; rapid coloration indicates the presence of adulterants such as amphetamines (orange\/red), sugars (brown), or synthetic cathinones.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"21,1,0\"><b data-path-to-node=\"21,1,0\" data-index-in-node=\"0\">Instrumental Profiling:<\/b><\/p>\n<ul data-path-to-node=\"21,1,1\">\n<li>\n<p data-path-to-node=\"21,1,1,0,0\"><b data-path-to-node=\"21,1,1,0,0\" data-index-in-node=\"0\">GC-MS (Electron Ionization, 70 eV):<\/b> Produces a diagnostic fragmentation pattern with a dominant base peak at <span class=\"math-inline\" data-math=\"m\/z\" data-index-in-node=\"109\">$m\/z$<\/span> 82 (<span class=\"math-inline\" data-math=\"[\\text{C}_5\\text{H}_8\\text{N}]^+\" data-index-in-node=\"117\">$[\\text{C}_5\\text{H}_8\\text{N}]^+$<\/span>, the methylpyrrolinium ion), along with characteristic diagnostic fragments at <span class=\"math-inline\" data-math=\"m\/z\" data-index-in-node=\"229\">$m\/z$<\/span> 182 (<span class=\"math-inline\" data-math=\"[M - \\text{C}_6\\text{H}_5\\text{COOH}]^+\" data-index-in-node=\"238\">$[M &#8211; \\text{C}_6\\text{H}_5\\text{COOH}]^+$<\/span>), <span class=\"math-inline\" data-math=\"m\/z\" data-index-in-node=\"280\">$m\/z$<\/span> 77 (phenyl cation), and a low-abundance molecular ion at <span class=\"math-inline\" data-math=\"m\/z\" data-index-in-node=\"341\">$m\/z$<\/span> 303.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"21,1,1,1,0\"><b data-path-to-node=\"21,1,1,1,0\" data-index-in-node=\"0\">HPLC-DAD \/ LC-MS\/MS:<\/b> Used for the simultaneous quantification of cocaine purity alongside adulterants (levamisole, phenacetin, caffeine) and trace processing solvents.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"22\"><b data-path-to-node=\"22\" data-index-in-node=\"0\">Regulatory Classification &amp; Handling Controls<\/b><\/p>\n<ul data-path-to-node=\"23\">\n<li>\n<p data-path-to-node=\"23,0,0\"><b data-path-to-node=\"23,0,0\" data-index-in-node=\"0\">Controlled Substance Classification:<\/b> Cocaine is classified as a Schedule II controlled substance under the United States Controlled Substances Act (due to historically retained, highly restricted clinical uses in ENT surgery), a Class A controlled drug in the United Kingdom under the Misuse of Drugs Act 1971, and listed under Schedule II of the UN Single Convention on Narcotic Drugs, 1961.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"23,1,0\"><b data-path-to-node=\"23,1,0\" data-index-in-node=\"0\">Compliance Requirements:<\/b> Possession, acquisition, analysis, and disposal require authorized Schedule II analytical researcher registration, secure double-lock vault containment, and continuous chain-of-custody documentation.<\/p>\n<\/li>\n<\/ul>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div> \n","protected":false},"excerpt":{"rendered":"<p>Cocaine Hydrochloride (benzoylmethylecgonine hydrochloride) Analytical Reference Standard is a high-purity, certified matrix designed for forensic toxicology laboratories, seized contraband profiling, and mass spectrometry calibration. Reflecting the chemical and alkaloidal characteristics of illicit cocaine exhibits processed in South American (Colombian) supply chains, this reference material assists analytical chemists in quantifying active tropane alkaloid purity, identifying synthesis byproducts (such as cinnamoylcocaine and ecgonine methyl ester), and screening for prevalent manufacturing-level adulterants (such as levamisole and phenacetin). Strictly restricted to certified forensic, clinical, and academic research institutions. Not for human or veterinary consumption.<\/p>","protected":false},"featured_media":10952,"comment_status":"open","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[290],"product_tag":[1161,949,1160,886,1164,1162,932,1165,919,1163],"class_list":["post-10951","product","type-product","status-publish","has-post-thumbnail","product_cat-research-chemicals","product_tag-benzoylmethylecgonine","product_tag-cocaine-hydrochloride","product_tag-colombian-cocaine-exhibit","product_tag-controlled-substance","product_tag-dat-inhibitor","product_tag-forensic-reference-standard","product_tag-gc-ms-standard","product_tag-levamisole-adulterant-screening","product_tag-toxicology-reference","product_tag-tropane-alkaloid","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Pure Colombian Cocaine \u2744\ufe0f\u26c4\ufe0f 100% RAW UNCUT<\/title>\n<meta name=\"description\" content=\"Cocaine hydrochloride analytical reference standard: Forensic alkaloid profiling, DAT\/NET\/SERT inhibition, levamisole adulterant screening, and GC-MS identificatio\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/europepharmacy.eu\/it\/shop\/10951\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pure Colombian Cocaine \u2744\ufe0f\u26c4\ufe0f 100% RAW UNCUT\" \/>\n<meta property=\"og:description\" content=\"Cocaine Hydrochloride (benzoylmethylecgonine hydrochloride) Analytical Reference Standard is a high-purity, certified matrix designed for forensic toxicology laboratories, seized contraband profiling, and mass spectrometry calibration. Reflecting the chemical and alkaloidal characteristics of illicit cocaine exhibits processed in South American (Colombian) supply chains, this reference material assists analytical chemists in quantifying active tropane alkaloid purity, identifying synthesis byproducts (such as cinnamoylcocaine and ecgonine methyl ester), and screening for prevalent manufacturing-level adulterants (such as levamisole and phenacetin). Strictly restricted to certified forensic, clinical, and academic research institutions. 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