{"id":10758,"date":"2026-09-17T13:52:59","date_gmt":"2026-09-17T13:52:59","guid":{"rendered":"https:\/\/europepharmacy.eu\/?post_type=product&#038;p=10758"},"modified":"2026-09-17T13:53:00","modified_gmt":"2026-09-17T13:53:00","slug":"180mg-xtc-pills","status":"publish","type":"product","link":"https:\/\/europepharmacy.eu\/es\/shop\/180mg-xtc-pills\/","title":{"rendered":"180mg Xtc Pills"},"content":{"rendered":"<p data-path-to-node=\"8\">Medical S-Isomer Ketamine (Esketamine hydrochloride) delivers the purified <span class=\"math-inline\" data-math=\"(S)\\text{-(+)}\" data-index-in-node=\"75\">$(S)\\text{-(+)}$<\/span> enantiomer of the arylcyclohexylamine derivative ketamine in standardized clinical formulations (e.g., Ketanest-S\u00ae injectable solution, Spravato\u00ae nasal spray). Clinically preferred over racemic mixtures in targeted settings due to higher clearance, lower required hypnotic dosages, and reduced post-anesthetic cognitive recovery intervals, medical S-ketamine modulates central glutamatergic pathways to deliver dual anesthetic and neurotrophic effects.<\/p>\n<p data-path-to-node=\"9\"><b data-path-to-node=\"9\" data-index-in-node=\"0\">Clinical Profile &amp; Pharmaceutical Formulations<\/b><\/p>\n<ul data-path-to-node=\"10\">\n<li>\n<p data-path-to-node=\"10,0,0\"><b data-path-to-node=\"10,0,0\" data-index-in-node=\"0\">Active Pharmaceutical Ingredient:<\/b> Esketamine Hydrochloride (equivalent to <span class=\"math-inline\" data-math=\"(S)\\text{-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one}\" data-index-in-node=\"74\">$(S)\\text{-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one}$<\/span>).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,1,0\"><b data-path-to-node=\"10,1,0\" data-index-in-node=\"0\">Available Formulations:<\/b><\/p>\n<ul data-path-to-node=\"10,1,1\">\n<li>\n<p data-path-to-node=\"10,1,1,0,0\"><i data-path-to-node=\"10,1,1,0,0\" data-index-in-node=\"0\">Injectable Solution (Ketanest-S):<\/i> Sterile aqueous solution (typically 5 mg\/mL or 25 mg\/mL) intended for slow intravenous (IV) or intramuscular (IM) administration in perioperative and emergency environments.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,1,1,1,0\"><i data-path-to-node=\"10,1,1,1,0\" data-index-in-node=\"0\">Intranasal Solution (Spravato):<\/i> Single-use nasal spray devices delivering a precise 28 mg dose (two sprays, 14 mg per spray) utilizing a mucosal delivery matrix for psychiatric protocols.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li>\n<p data-path-to-node=\"10,2,0\"><b data-path-to-node=\"10,2,0\" data-index-in-node=\"0\">Hemodynamic Advantage:<\/b> Provides robust surgical anesthesia and analgesia while preserving spontaneous airway reflexes and maintaining peripheral vascular tone via central sympathomimetic outflow, making it valuable in hemodynamic instability or shock.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"11\"><b data-path-to-node=\"11\" data-index-in-node=\"0\">Pharmacodynamics &amp; Mechanism of Action<\/b><\/p>\n<ul data-path-to-node=\"12\">\n<li>\n<p data-path-to-node=\"12,0,0\"><b data-path-to-node=\"12,0,0\" data-index-in-node=\"0\">NMDA Receptor Blockade:<\/b> Functions as an uncompetitive, open-channel blocker of ionotropic <span class=\"math-inline\" data-math=\"N\" data-index-in-node=\"90\">$N$<\/span>-methyl-D-aspartate (NMDA) glutamate receptors, binding to the phencyclidine site within the ion channel pore to arrest calcium (<span class=\"math-inline\" data-math=\"\\text{Ca}^{2+}\" data-index-in-node=\"220\">$\\text{Ca}^{2+}$<\/span>) influx.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"12,1,0\"><b data-path-to-node=\"12,1,0\" data-index-in-node=\"0\">Glutamatergic Burst &amp; Synaptic Plasticity:<\/b> Transient inhibition of NMDA receptors on GABAergic interneurons induces a disinhibition of cortical pyramidal neurons. The resulting localized glutamate release stimulates post-synaptic <span class=\"math-inline\" data-math=\"\\alpha\" data-index-in-node=\"230\">$\\alpha$<\/span>-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, triggering the secretion of brain-derived neurotrophic factor (BDNF) and activating the mammalian target of rapamycin (mTOR) pathway. This cascade promotes rapid synaptogenesis and restores spine density within the prefrontal cortex within hours.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"12,2,0\"><b data-path-to-node=\"12,2,0\" data-index-in-node=\"0\">Secondary Targets:<\/b> Exerts weak allosteric modulatory effects at opioid <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"71\">$\\mu$<\/span> y <span class=\"math-inline\" data-math=\"\\kappa\" data-index-in-node=\"79\">$\\kappa$<\/span> receptors, monoamine transporters (dopamine, serotonin, norepinephrine), and nicotinic acetylcholine receptors.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"13\"><b data-path-to-node=\"13\" data-index-in-node=\"0\">Pharmacokinetics &amp; Metabolism<\/b><\/p>\n<ul data-path-to-node=\"14\">\n<li>\n<p data-path-to-node=\"14,0,0\"><b data-path-to-node=\"14,0,0\" data-index-in-node=\"0\">Onset &amp; Duration:<\/b> IV induction induces surgical anesthesia within 30 to 60 seconds; intranasal administration achieves peak plasma concentrations (<span class=\"math-inline\" data-math=\"C_{\\max}\" data-index-in-node=\"147\">$C_{\\max}$<\/span>) within 20 to 40 minutes.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,1,0\"><b data-path-to-node=\"14,1,0\" data-index-in-node=\"0\">Biotransformation:<\/b> Extensively metabolized hepatically via cytochrome P450 enzymes (predominantly CYP2B6 and CYP3A4) through <span class=\"math-inline\" data-math=\"N\" data-index-in-node=\"125\">$N$<\/span>-demethylation to active <span class=\"math-inline\" data-math=\"(S)\\text{-norketamine}\" data-index-in-node=\"151\">$(S)\\text{-norketamine}$<\/span>, which exhibits roughly one-third of the parent compound&#8217;s anesthetic activity. Subsequent hydroxylation and glucuronidation facilitate renal excretion.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,2,0\"><b data-path-to-node=\"14,2,0\" data-index-in-node=\"0\">Elimination:<\/b> Displays a mean terminal plasma elimination half-life of 2 to 4 hours, characterized by a rapid distribution phase (<span class=\"math-inline\" data-math=\"\\alpha\" data-index-in-node=\"129\">$\\alpha$<\/span>-phase) and comprehensive renal clearance.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"15\"><b data-path-to-node=\"15\" data-index-in-node=\"0\">Indications &amp; Clinical Administration Protocols<\/b><\/p>\n<ul data-path-to-node=\"16\">\n<li>\n<p data-path-to-node=\"16,0,0\"><b data-path-to-node=\"16,0,0\" data-index-in-node=\"0\">Treatment-Resistant Depression (TRD):<\/b> Administered intranasally in conjunction with an oral antidepressant for adults with MDD who have not responded adequately to at least two different antidepressants, or for MDD with acute suicidal ideation.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,1,0\"><b data-path-to-node=\"16,1,0\" data-index-in-node=\"0\">Anesthesia &amp; Analgesia:<\/b> Utilized as a sole anesthetic agent for diagnostic and short surgical procedures, as an induction agent prior to maintenance with other anesthetics, or as an opioid-sparing adjuvant for refractory perioperative pain.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"16,2,0\"><b data-path-to-node=\"16,2,0\" data-index-in-node=\"0\">Strict Healthcare Monitoring (REMS):<\/b> Due to the risks of serious adverse outcomes resulting from sedation and dissociation, psychiatric administration is restricted to certified healthcare facilities under a Risk Evaluation and Mitigation Strategy (REMS) program requiring at least two hours of post-administration clinical observation.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"17\"><b data-path-to-node=\"17\" data-index-in-node=\"0\">Important Safety Information &amp; Boxed Warnings<\/b><\/p>\n<ul data-path-to-node=\"18\">\n<li>\n<p data-path-to-node=\"18,0,0\"><b data-path-to-node=\"18,0,0\" data-index-in-node=\"0\">Sedation and Dissociation:<\/b> Induces dose-dependent perceptual alterations, derealization, depersonalization, and profound sedation. Patients must be monitored by a healthcare provider until clinically stable.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,1,0\"><b data-path-to-node=\"18,1,0\" data-index-in-node=\"0\">Cardiovascular Stimulation:<\/b> Transient, significant elevations in systolic and diastolic blood pressure, as well as resting heart rate, frequently occur post-administration. Contraindicated in patients with severe aneurysmal vascular disease or uncontrolled hypertension.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,2,0\"><b data-path-to-node=\"18,2,0\" data-index-in-node=\"0\">Abuse and Misuse:<\/b> Classified as a Schedule III controlled substance due to potential for psychological and physiological dependence, misuse, and recreational diversion.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,3,0\"><b data-path-to-node=\"18,3,0\" data-index-in-node=\"0\">Ulcerative Cystitis Risk:<\/b> Chronic, high-frequency, non-medical exposure is associated with severe lower urinary tract pathology, including hemorrhagic cystitis, bladder wall fibrosis, and secondary hydronephrosis<\/p>\n<\/li>\n<\/ul>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Medical S-Isomer Ketamine (Esketamine hydrochloride) is a pharmaceutical-grade, Schedule III dissociative anesthetic and rapid-acting antidepressant. Comprising the isolated dextrorotatory <span class=\"math-inline\" data-math=\"(S)\\text{-(+)}\" data-index-in-node=\"189\">$(S)\\text{-(+)}$<\/span> optical enantiomer of ketamine, it possesses approximately double the anesthetic and analgesic potency of racemic ketamine and 3- to 4-fold the NMDA receptor affinity of the <span class=\"math-inline\" data-math=\"(R)\\text{-(-)}\" data-index-in-node=\"378\">$(R)\\text{-(-)}$<\/span> isomer. Formulated as a sterile aqueous solution for intravenous\/intramuscular injection or as an FDA-approved nasal spray (Spravato\u00ae), it is indicated for surgical anesthesia, acute procedural analgesia, and treatment-resistant depression under direct medical supervision. Dispensed strictly by valid prescription.<\/p>","protected":false},"featured_media":10760,"comment_status":"open","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[688,108,107],"product_tag":[935,1041,1039,936,1043,1042,934,940,1040,938],"class_list":["post-10758","product","type-product","status-publish","has-post-thumbnail","product_cat-antidepressants","product_cat-pain-relief","product_cat-painkillers","product_tag-esketamine-hcl","product_tag-ketanest-s","product_tag-medical-s-ketamine","product_tag-nmda-receptor-antagonist","product_tag-prescription-anesthetic","product_tag-procedural-anesthesia","product_tag-s-isomer-ketamine","product_tag-schedule-iii-substance","product_tag-spravato-generic","product_tag-treatment-resistant-depression","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>180mg Xtc Pills<\/title>\n<meta name=\"description\" content=\"Medical S-Isomer Ketamine (Esketamine) solution: Schedule III NMDA receptor antagonist for procedural anesthesia, analgesia, and treatment-resistant depression.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/europepharmacy.eu\/es\/shop\/180mg-xtc-pills\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"180mg Xtc Pills\" \/>\n<meta property=\"og:description\" content=\"Medical S-Isomer Ketamine (Esketamine hydrochloride) is a pharmaceutical-grade, Schedule III dissociative anesthetic and rapid-acting antidepressant. Comprising the isolated dextrorotatory $(S)text{-(+)}$ optical enantiomer of ketamine, it possesses approximately double the anesthetic and analgesic potency of racemic ketamine and 3- to 4-fold the NMDA receptor affinity of the $(R)text{-(-)}$ isomer. Formulated as a sterile aqueous solution for intravenous\/intramuscular injection or as an FDA-approved nasal spray (Spravato\u00ae), it is indicated for surgical anesthesia, acute procedural analgesia, and treatment-resistant depression under direct medical supervision. 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