{"id":10705,"date":"2026-09-17T07:44:25","date_gmt":"2026-09-17T07:44:25","guid":{"rendered":"https:\/\/europepharmacy.eu\/?post_type=product&#038;p=10705"},"modified":"2026-09-17T07:48:45","modified_gmt":"2026-09-17T07:48:45","slug":"oxeltra","status":"publish","type":"product","link":"https:\/\/europepharmacy.eu\/de\/shop\/oxeltra\/","title":{"rendered":"Oxeltra"},"content":{"rendered":"<p id=\"p-rc_3ba9819342f35287-34\" data-path-to-node=\"8\"><span class=\"citation-31 citation-end-31\">Oxeltra prolonged-release oral tablets deliver oxycodone hydrochloride, a semi-synthetic <\/span><span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"90\">$\\mu$<\/span><span class=\"citation-30 citation-end-30\">-opioid receptor agonist, via an advanced controlled-release matrix.<\/span> <span class=\"citation-29 citation-end-29\">Formulated for 12-hourly administration, Oxeltra provides stable therapeutic analgesia for chronic severe pain conditions\u2014such as oncological pain and severe refractory postoperative discomfort\u2014minimizing peak-and-trough plasma fluctuations associated with immediate-release opioids.<\/span><\/p>\n<p data-path-to-node=\"9\"><b data-path-to-node=\"9\" data-index-in-node=\"0\">Clinical Profile &amp; Physical Presentation<\/b><\/p>\n<ul data-path-to-node=\"10\">\n<li>\n<p id=\"p-rc_3ba9819342f35287-35\" data-path-to-node=\"10,0,0\"><b data-path-to-node=\"10,0,0\" data-index-in-node=\"0\">Active Ingredient:<\/b> <span class=\"citation-28 citation-end-28\">Oxycodone Hydrochloride (available in 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, and 80 mg strengths).<\/span><\/p>\n<\/li>\n<li>\n<p id=\"p-rc_3ba9819342f35287-36\" data-path-to-node=\"10,1,0\"><b data-path-to-node=\"10,1,0\" data-index-in-node=\"0\">Physical Identification:<\/b> <span class=\"citation-27 citation-end-27\">Round, biconvex, film-coated tablets debossed with &#8220;OX&#8221; followed by the corresponding milligram strength (e.g., &#8220;OX 10&#8221;, &#8220;OX 20&#8221;, &#8220;OX 80&#8221;).<\/span><\/p>\n<\/li>\n<li>\n<p id=\"p-rc_3ba9819342f35287-37\" data-path-to-node=\"10,2,0\"><b data-path-to-node=\"10,2,0\" data-index-in-node=\"0\">Release Profile:<\/b> <span class=\"citation-26 citation-end-26\">Engineered with a biphasic release mechanism that delivers an initial rapid-release component to facilitate onset of analgesia, followed by sustained, continuous dissolution across a 12-hour dosing interval.<\/span><\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"11\"><b data-path-to-node=\"11\" data-index-in-node=\"0\">Pharmacodynamics &amp; Mechanism of Action<\/b><\/p>\n<ul data-path-to-node=\"12\">\n<li>\n<p data-path-to-node=\"12,0,0\"><b data-path-to-node=\"12,0,0\" data-index-in-node=\"0\">Receptor Affinity:<\/b> Acts as a full agonist at central and spinal <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"64\">$\\mu$<\/span>-opioid receptors, with secondary affinity for <span class=\"math-inline\" data-math=\"\\kappa\" data-index-in-node=\"114\">$\\kappa$<\/span>-opioid receptors.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"12,1,0\"><b data-path-to-node=\"12,1,0\" data-index-in-node=\"0\">Intracellular Signal Transduction:<\/b> Receptor binding stimulates inhibitory G-proteins (<span class=\"math-inline\" data-math=\"G_i\/G_o\" data-index-in-node=\"86\">$G_i\/G_o$<\/span>), inhibiting adenylyl cyclase, reducing intracellular cyclic adenosine monophosphate (cAMP) accumulation, closing voltage-dependent N-type calcium channels, and opening inwardly rectifying potassium channels.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"12,2,0\"><b data-path-to-node=\"12,2,0\" data-index-in-node=\"0\">Nociceptive Inhibition:<\/b> Hyperpolarizes primary afferent nerve terminals, suppressing the presynaptic exocytosis of pain neurotransmitters (including substance P and glutamate) and altering sensory-affective pain perception in the cerebral cortex and periaqueductal gray.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"13\"><b data-path-to-node=\"13\" data-index-in-node=\"0\">Pharmacokinetics &amp; Metabolism<\/b><\/p>\n<ul data-path-to-node=\"14\">\n<li>\n<p data-path-to-node=\"14,0,0\"><b data-path-to-node=\"14,0,0\" data-index-in-node=\"0\">Absorption:<\/b> Demonstrates high oral bioavailability (approximately 60% to 87%) relative to morphine; peak plasma concentrations (<span class=\"math-inline\" data-math=\"C_{\\max}\" data-index-in-node=\"128\">$C_{\\max}$<\/span>) are reached within 4 to 5 hours following ingestion of the prolonged-release tablet.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,1,0\"><b data-path-to-node=\"14,1,0\" data-index-in-node=\"0\">Metabolism:<\/b> Primarily metabolized hepatically via cytochrome P450 enzymes\u2014predominantly CYP3A4 to noroxycodone, with CYP2D6 catalyzing conversion to active oxymorphone.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,2,0\"><b data-path-to-node=\"14,2,0\" data-index-in-node=\"0\">Clearance:<\/b> Mean plasma elimination half-life is approximately 4.5 to 5 hours, with parent compound and polar conjugated metabolites cleared primarily via the kidneys.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"15\"><b data-path-to-node=\"15\" data-index-in-node=\"0\">Prescribing Guidelines &amp; Administration Protocol<\/b><\/p>\n<ul data-path-to-node=\"16\">\n<li>\n<p id=\"p-rc_3ba9819342f35287-38\" data-path-to-node=\"16,0,0\"><b data-path-to-node=\"16,0,0\" data-index-in-node=\"0\">Strict Whole-Tablet Ingestion:<\/b> <span class=\"citation-25 citation-end-25\">Tablets must be swallowed whole with water and never crushed, broken, chewed, or dissolved.<\/span> Disrupting the tablet matrix compromises the prolonged-release mechanism, leading to rapid systemic dose-dumping of a potentially lethal quantity of oxycodone.<\/p>\n<\/li>\n<li>\n<p id=\"p-rc_3ba9819342f35287-39\" data-path-to-node=\"16,1,0\"><b data-path-to-node=\"16,1,0\" data-index-in-node=\"0\">High-Dose Restriction (60 mg &amp; 80 mg):<\/b> <span class=\"citation-24 citation-end-24\">Higher strengths are contraindicated in opioid-naive patients and are reserved strictly for individuals who have demonstrated sustained opioid tolerance.<\/span><\/p>\n<\/li>\n<li>\n<p id=\"p-rc_3ba9819342f35287-40\" data-path-to-node=\"16,2,0\"><b data-path-to-node=\"16,2,0\" data-index-in-node=\"0\">Discontinuation Protocol:<\/b> <span class=\"citation-23 citation-end-23\">When discontinuing therapy, doses must be gradually tapered under physician direction to avoid acute autonomic withdrawal manifestations.<\/span><\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"17\"><b data-path-to-node=\"17\" data-index-in-node=\"0\">Important Safety Information &amp; Boxed Warnings<\/b><\/p>\n<ul data-path-to-node=\"18\">\n<li>\n<p id=\"p-rc_3ba9819342f35287-41\" data-path-to-node=\"18,0,0\"><b data-path-to-node=\"18,0,0\" data-index-in-node=\"0\">Addiction, Abuse, and Misuse:<\/b> <span class=\"citation-22 citation-end-22\">Oxeltra is a controlled opioid analgesic carrying substantial risks of substance misuse, psychological and physiological dependence, and diversion.<\/span><\/p>\n<\/li>\n<li>\n<p id=\"p-rc_3ba9819342f35287-42\" data-path-to-node=\"18,1,0\"><b data-path-to-node=\"18,1,0\" data-index-in-node=\"0\">Life-Threatening Respiratory Depression:<\/b> <span class=\"citation-21 citation-end-21\">Severe or fatal respiratory depression can occur at any stage of therapy, with greatest susceptibility occurring during treatment initiation or following dosage escalation.<\/span><\/p>\n<\/li>\n<li>\n<p id=\"p-rc_3ba9819342f35287-43\" data-path-to-node=\"18,2,0\"><b data-path-to-node=\"18,2,0\" data-index-in-node=\"0\">Risks with CNS Depressants:<\/b> <span class=\"citation-20 citation-end-20\">Co-administration with benzodiazepines, barbiturates, other sedatives, or alcohol can cause severe sedation, respiratory collapse, coma, and mortality.<\/span><\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,3,0\"><b data-path-to-node=\"18,3,0\" data-index-in-node=\"0\">Accidental Exposure:<\/b> Ingestion of even a single dose, especially by children, can cause fatal respiratory arrest. Secure storage in a tamper-resistant lockbox is required.<\/p>\n<\/li>\n<\/ul>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p><span class=\"citation-36 citation-end-36\">Oxeltra (oxycodone hydrochloride prolonged-release) is a potent, prescription-only opioid analgesic indicated for the continuous management of moderate to severe pain requiring round-the-clock intervention when non-opioid treatments are inadequate.<\/span> <span class=\"citation-35 citation-end-35\">Engineered as a 12-hour biphasic prolonged-release tablet bioequivalent to standard prolonged-release oxycodone formulations, it selectively activates central <\/span><span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"409\">$\\mu$<\/span><span class=\"citation-34 citation-end-34\">-opioid receptors to attenuate ascending nociceptive signaling under strict medical supervision.<\/span> <span class=\"citation-33 citation-end-33\">Available in multiple strengths ranging from 5 mg to 80 mg.<\/span> <span class=\"citation-32 citation-end-32\">Valid prescription required.<\/span><\/p>","protected":false},"featured_media":10707,"comment_status":"open","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108,107],"product_tag":[1002,1003,1001,968,997,998,999,1000,893,866],"class_list":["post-10705","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_cat-painkillers","product_tag-12-hour-pain-relief","product_tag-controlled-drug","product_tag-opioid-analgesic","product_tag-oral-oxycodone-tablet","product_tag-oxeltra","product_tag-oxeltra-prolonged-release","product_tag-oxycodone-prolonged-release","product_tag-pain-relief","product_tag-prescription-painkillers","product_tag-schedule-ii-opioid","instock","sale","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Oxeltra<\/title>\n<meta name=\"description\" content=\"Oxeltra (oxycodone hydrochloride) prolonged-release tablets: 12-hour opioid analgesic for moderate to severe pain. 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