{"id":10640,"date":"2026-09-16T09:54:32","date_gmt":"2026-09-16T09:54:32","guid":{"rendered":"https:\/\/europepharmacy.eu\/?post_type=product&#038;p=10640"},"modified":"2026-09-16T09:54:51","modified_gmt":"2026-09-16T09:54:51","slug":"oxycodone-hcl-80-mg","status":"publish","type":"product","link":"https:\/\/europepharmacy.eu\/de\/shop\/oxycodone-hcl-80-mg\/","title":{"rendered":"Oxycodone HCl 80 mg"},"content":{"rendered":"<p data-path-to-node=\"8\">Oxycodone Hydrochloride 80 mg extended-release oral tablets deliver a high concentration of a semi-synthetic <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"109\">$\\mu$<\/span>-opioid receptor agonist designed to provide sustained 12-hour analgesia. Indicated solely for opioid-tolerant patients managing persistent, severe chronic pain\u2014such as advanced cancer pain or intractable non-malignant chronic conditions\u2014the formulation maintains stable plasma drug concentrations over an extended dosing interval, minimizing breakthrough pain episodes.<\/p>\n<p data-path-to-node=\"9\"><b data-path-to-node=\"9\" data-index-in-node=\"0\">Clinical Profile &amp; Physical Identification<\/b><\/p>\n<ul data-path-to-node=\"10\">\n<li>\n<p data-path-to-node=\"10,0,0\"><b data-path-to-node=\"10,0,0\" data-index-in-node=\"0\">Active Ingredient:<\/b> Oxycodone Hydrochloride (80 mg)<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,1,0\"><b data-path-to-node=\"10,1,0\" data-index-in-node=\"0\">Appearance &amp; Imprint:<\/b> Round, green, biconvex tablet debossed with &#8220;OC&#8221; on one side and &#8220;80&#8221; on the reverse.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,2,0\"><b data-path-to-node=\"10,2,0\" data-index-in-node=\"0\">Mechanism of Action:<\/b> Acts as a full agonist at central nervous system <span class=\"math-inline\" data-math=\"\\mu\" data-index-in-node=\"70\">$\\mu$<\/span>-opioid receptors. Receptor binding couples to inhibitory G-proteins, inhibiting adenylyl cyclase, closing voltage-gated calcium channels, and opening inwardly rectifying potassium channels. This hyperpolarizes ascending pain projection neurons, dampening nociceptive signal transmission across the spinal dorsal horn and thalamic pathways.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,3,0\"><b data-path-to-node=\"10,3,0\" data-index-in-node=\"0\">Pharmacokinetics &amp; Release Profile:<\/b> Provides a biphasic release pattern with an initial absorption phase followed by prolonged systemic delivery over 12 hours. Peak concentrations occur within 4.5 to 5 hours, with hepatic biotransformation governed predominantly by CYP3A4 (forming noroxycodone) and CYP2D6 (forming oxymorphone).<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"11\"><b data-path-to-node=\"11\" data-index-in-node=\"0\">Opioid Tolerance Requirement &amp; Prescribing Guidelines<\/b><\/p>\n<ul data-path-to-node=\"12\">\n<li>\n<p data-path-to-node=\"12,0,0\"><b data-path-to-node=\"12,0,0\" data-index-in-node=\"0\">Opioid-Tolerant Restriction:<\/b> Single doses greater than 40 mg or total daily doses greater than 80 mg are restricted <b data-path-to-node=\"12,0,0\" data-index-in-node=\"116\">strictly<\/b> to opioid-tolerant patients. Patients are considered opioid-tolerant if they have received at least 60 mg oral morphine daily, 30 mg oral oxycodone daily, or an equianalgesic dose of another opioid continuously for one week or longer.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"12,1,0\"><b data-path-to-node=\"12,1,0\" data-index-in-node=\"0\">Fatal Risk in Opioid-Naive Patients:<\/b> Administration of an 80 mg oxycodone dose to an opioid-naive individual can precipitate immediate, fatal respiratory arrest.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"12,2,0\"><b data-path-to-node=\"12,2,0\" data-index-in-node=\"0\">Administration Integrity:<\/b> Tablets must be swallowed whole. Chewing, crushing, splitting, snorting, or dissolving the tablet destroys the extended-release mechanism, leading to rapid systemic dumping of a potentially lethal dose of oxycodone.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"13\"><b data-path-to-node=\"13\" data-index-in-node=\"0\">Important Safety Information &amp; Boxed Warnings<\/b><\/p>\n<ul data-path-to-node=\"14\">\n<li>\n<p data-path-to-node=\"14,0,0\"><b data-path-to-node=\"14,0,0\" data-index-in-node=\"0\">Addiction, Abuse, and Misuse:<\/b> Oxycodone is a Schedule II controlled substance carrying high risks of psychological and physical dependence, severe misuse, and diversion, which can lead to fatal overdose.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,1,0\"><b data-path-to-node=\"14,1,0\" data-index-in-node=\"0\">Life-Threatening Respiratory Depression:<\/b> Severe, potentially fatal respiratory depression can occur at any stage of therapy, with highest vulnerability present during dosage adjustments or improper ingestion.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,2,0\"><b data-path-to-node=\"14,2,0\" data-index-in-node=\"0\">Concomitant Use with Benzodiazepines &amp; CNS Depressants:<\/b> Concurrent administration with benzodiazepines, tranquilizers, sedatives, or alcohol can cause profound lethargy, respiratory collapse, coma, and death.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,3,0\"><b data-path-to-node=\"14,3,0\" data-index-in-node=\"0\">Accidental Ingestion:<\/b> Ingestion of a single tablet by a child or unauthorized person<\/p>\n<\/li>\n<\/ul>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Oxycodone Hydrochloride 80 mg (imprint &#8220;OC 80&#8221;) is a high-potency, extended-release Schedule II opioid agonist indicated strictly for the management of severe, chronic pain requiring continuous, round-the-clock, long-term opioid analgesia when alternative therapies are inadequate. Formulated as a round, green controlled-release tablet, this 80 mg strength is reserved exclusively for opioid-tolerant patients under close medical monitoring. Dispensed strictly by valid prescription<\/p>","protected":false},"featured_media":10642,"comment_status":"open","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108,107],"product_tag":[966,967,964,963,965,968,921,263,866,925],"class_list":["post-10640","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_cat-painkillers","product_tag-around-the-clock-pain-relief","product_tag-c-ii-prescription","product_tag-green-oc-80-pill","product_tag-oc-80","product_tag-opioid-tolerant-analgesic","product_tag-oral-oxycodone-tablet","product_tag-oxycodone-extended-release","product_tag-oxycontin-80mg","product_tag-schedule-ii-opioid","product_tag-severe-chronic-pain","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Oxycodone HCl 80 mg<\/title>\n<meta name=\"description\" content=\"Oxycodone HCl 80 mg (OC 80) extended-release tablets: Schedule II opioid analgesic for severe chronic pain. 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