{"id":10629,"date":"2026-09-16T09:40:33","date_gmt":"2026-09-16T09:40:33","guid":{"rendered":"https:\/\/europepharmacy.eu\/?post_type=product&#038;p=10629"},"modified":"2026-09-16T16:33:06","modified_gmt":"2026-09-16T16:33:06","slug":"coke","status":"publish","type":"product","link":"https:\/\/europepharmacy.eu\/de\/shop\/coke\/","title":{"rendered":"Coke"},"content":{"rendered":"<p data-path-to-node=\"8\">Coke Hydrochloride is a naturally occurring tropane alkaloid derived from the leaves of the <i data-path-to-node=\"8\" data-index-in-node=\"95\">Erythroxylum coca<\/i> plant. Chemically designated as methyl <span class=\"math-inline\" data-math=\"(1R,2R,3S,5S)\\text{-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate hydrochloride}\" data-index-in-node=\"152\">$(1R,2R,3S,5S)\\text{-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate hydrochloride}$<\/span>, it possesses a dual pharmacological mechanism, acting simultaneously as a local anesthetic and a potent triple monoamine reuptake inhibitor.<\/p>\n<p data-path-to-node=\"9\"><b data-path-to-node=\"9\" data-index-in-node=\"0\">Chemical &amp; Pharmacodynamic Profile<\/b><\/p>\n<ul data-path-to-node=\"10\">\n<li>\n<p data-path-to-node=\"10,0,0\"><b data-path-to-node=\"10,0,0\" data-index-in-node=\"0\">Molecular Formula &amp; Mass:<\/b> <span class=\"math-inline\" data-math=\"\\text{C}_{17}\\text{H}_{21}\\text{NO}_4 \\cdot \\text{HCl}\" data-index-in-node=\"26\">$\\text{C}_{17}\\text{H}_{21}\\text{NO}_4 \\cdot \\text{HCl}$<\/span> | 339.81 g\/mol<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,1,0\"><b data-path-to-node=\"10,1,0\" data-index-in-node=\"0\">Peripheral Local Anesthesia:<\/b> Reversibly binds to and blocks voltage-gated sodium (<span class=\"math-inline\" data-math=\"\\text{Na}^{+}\" data-index-in-node=\"82\">$\\text{Na}^{+}$<\/span>) channels along neuronal cell membranes. This inhibits transient sodium permeability, arresting the initiation and propagation of action potentials along sensory nerve fibers to produce localized analgesia.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,2,0\"><b data-path-to-node=\"10,2,0\" data-index-in-node=\"0\">Intrinsic Vasoconstriction:<\/b> Uniquely among local anesthetics, cocaine inhibits the presynaptic reuptake of norepinephrine via the norepinephrine transporter (<span class=\"math-inline\" data-math=\"\\text{NET}\" data-index-in-node=\"158\">$\\text{NET}$<\/span>), leading to localized <span class=\"math-inline\" data-math=\"\\alpha_1\" data-index-in-node=\"192\">$\\alpha_1$<\/span>-adrenergic receptor stimulation, rapid vasoconstriction, and hemostasis in highly vascularized mucosal tissue.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"10,3,0\"><b data-path-to-node=\"10,3,0\" data-index-in-node=\"0\">Central Neurotransmission:<\/b> In the central nervous system, it acts as a competitive antagonist at monoamine reuptake transporters, exhibiting highest relative affinity for the dopamine transporter (<span class=\"math-inline\" data-math=\"\\text{DAT}\" data-index-in-node=\"197\">$\\text{DAT}$<\/span>), followed by the serotonin transporter (<span class=\"math-inline\" data-math=\"\\text{SERT}\" data-index-in-node=\"249\">$\\text{SERT}$<\/span>) and norepinephrine transporter (<span class=\"math-inline\" data-math=\"\\text{NET}\" data-index-in-node=\"294\">$\\text{NET}$<\/span>). This produces an accumulation of extracellular dopamine within the mesolimbic pathway.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"11\"><b data-path-to-node=\"11\" data-index-in-node=\"0\">Clinical Indications &amp; Analytical Applications<\/b><\/p>\n<ul data-path-to-node=\"12\">\n<li>\n<p data-path-to-node=\"12,0,0\"><b data-path-to-node=\"12,0,0\" data-index-in-node=\"0\">Surgical Anesthesia (Rx Only):<\/b> Indicated for the induction of local anesthesia of accessible mucous membranes prior to diagnostic, biopsy, or surgical interventions involving the oral cavity, larynx, and nasal cavities (e.g., rhinosurgery, sinus endoscopy).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"12,1,0\"><b data-path-to-node=\"12,1,0\" data-index-in-node=\"0\">Analytical &amp; Forensic Calibration:<\/b> Utilized in forensic toxicological laboratories as an analytical reference material to optimize chromatographic retention times and mass spectral fragmentation patterns across gas chromatography-mass spectrometry (<span class=\"math-inline\" data-math=\"\\text{GC-MS}\" data-index-in-node=\"249\">$\\text{GC-MS}$<\/span>) and high-performance liquid chromatography (<span class=\"math-inline\" data-math=\"\\text{HPLC}\" data-index-in-node=\"307\">$\\text{HPLC}$<\/span>).<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"12,2,0\"><b data-path-to-node=\"12,2,0\" data-index-in-node=\"0\">Presumptive Assay Verification:<\/b> Serves as a reference control for verifying colorimetric transitions in cobalt thiocyanate (Scott test) presumptive screening protocols for tertiary amines.<\/p>\n<\/li>\n<\/ul>\n<p data-path-to-node=\"13\"><b data-path-to-node=\"13\" data-index-in-node=\"0\">Safety Disclosures &amp; Boxed Warnings<\/b><\/p>\n<ul data-path-to-node=\"14\">\n<li>\n<p data-path-to-node=\"14,0,0\"><b data-path-to-node=\"14,0,0\" data-index-in-node=\"0\">Abuse and Dependence:<\/b> Classified as a Schedule II controlled substance under the United States Controlled Substances Act (Class A in the UK; Schedule II of the UN 1961 Single Convention) due to high liability for psychological and physiological dependence, severe misuse, and diversion.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,1,0\"><b data-path-to-node=\"14,1,0\" data-index-in-node=\"0\">Cardiovascular &amp; Systemic Toxicity:<\/b> Systemic absorption carries dose-dependent risks of acute cardiovascular crisis, including severe tachycardia, malignant arterial hypertension, coronary vasospasm, fatal ventricular arrhythmias, and myocardial infarction.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,2,0\"><b data-path-to-node=\"14,2,0\" data-index-in-node=\"0\">Central Nervous System Risks:<\/b> Toxicity can manifest as severe agitation, acute delirium, tonic-clonic seizures, hyperthermia, and ischemic or hemorrhagic stroke.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"14,3,0\"><b data-path-to-node=\"14,3,0\" data-index-in-node=\"0\">Institutional Governance:<\/b> Procurement, custody, dispensing, and disposal require strict adherence to DEA registration mandates, secure vault storage, and perpetual inventory logging.<\/p>\n<\/li>\n<\/ul>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div> \n","protected":false},"excerpt":{"rendered":"<p>Coke Hydrochloride (benzoylmethylecgonine hydrochloride) is an ester local anesthetic and central nervous system stimulant. In clinical medicine, it is an FDA-approved Schedule II topical solution indicated for the induction of local anesthesia and vasoconstriction of accessible mucous membranes during diagnostic and surgical procedures of the nasal cavities and oral mucosa. In analytical chemistry and forensic toxicology, high-purity crystalline standards serve as calibrated benchmarks for quantitative mass spectrometry, presumptive assay validation, and monoamine transporter kinetic profiling. Available strictly by valid prescription or licensed institutional research authorization<\/p>","protected":false},"featured_media":10631,"comment_status":"open","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[711,108],"product_tag":[901,894,949,953,954,951,911,899,952,950],"class_list":["post-10629","product","type-product","status-publish","has-post-thumbnail","product_cat-muscle-relaxants","product_cat-pain-relief","product_tag-analytical-reference-standard","product_tag-c-ii-medication","product_tag-cocaine-hydrochloride","product_tag-dopamine-transporter-inhibitor","product_tag-ent-surgical-anesthetic","product_tag-ester-anesthetic","product_tag-forensic-testing-sample","product_tag-research-chemicals","product_tag-schedule-ii-substance","product_tag-topical-local-anesthetic","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Coke<\/title>\n<meta name=\"description\" content=\"Coke Hydrochloride analytical standard and Schedule II topical anesthetic reference for forensic testing, clinical pharmacology, and HPLC\/GC-MS assays.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/europepharmacy.eu\/de\/shop\/coke\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Coke\" \/>\n<meta property=\"og:description\" content=\"Coke Hydrochloride (benzoylmethylecgonine hydrochloride) is an ester local anesthetic and central nervous system stimulant. In clinical medicine, it is an FDA-approved Schedule II topical solution indicated for the induction of local anesthesia and vasoconstriction of accessible mucous membranes during diagnostic and surgical procedures of the nasal cavities and oral mucosa. In analytical chemistry and forensic toxicology, high-purity crystalline standards serve as calibrated benchmarks for quantitative mass spectrometry, presumptive assay validation, and monoamine transporter kinetic profiling. Available strictly by valid prescription or licensed institutional research authorization\" \/>\n<meta property=\"og:url\" content=\"https:\/\/europepharmacy.eu\/de\/shop\/coke\/\" \/>\n<meta property=\"og:site_name\" content=\"European Pharmacy\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-16T16:33:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/europepharmacy.eu\/wp-content\/uploads\/2026\/09\/photo_2026-09-16_11-39-18.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"960\" \/>\n\t<meta property=\"og:image:height\" content=\"1280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/shop\\\/coke\\\/\",\"url\":\"https:\\\/\\\/europepharmacy.eu\\\/shop\\\/coke\\\/\",\"name\":\"Coke\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/shop\\\/coke\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/shop\\\/coke\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/europepharmacy.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/photo_2026-09-16_11-39-18.jpg\",\"datePublished\":\"2026-09-16T09:40:33+00:00\",\"dateModified\":\"2026-09-16T16:33:06+00:00\",\"description\":\"Coke Hydrochloride analytical standard and Schedule II topical anesthetic reference for forensic testing, clinical pharmacology, and HPLC\\\/GC-MS assays.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/shop\\\/coke\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/europepharmacy.eu\\\/shop\\\/coke\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/shop\\\/coke\\\/#primaryimage\",\"url\":\"https:\\\/\\\/europepharmacy.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/photo_2026-09-16_11-39-18.jpg\",\"contentUrl\":\"https:\\\/\\\/europepharmacy.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/photo_2026-09-16_11-39-18.jpg\",\"width\":960,\"height\":1280},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/shop\\\/coke\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/europepharmacy.eu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\\\/\\\/europepharmacy.eu\\\/shop\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Coke\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/#website\",\"url\":\"https:\\\/\\\/europepharmacy.eu\\\/\",\"name\":\"European Pharmacy\",\"description\":\"Order Medication &amp; Pills Online\",\"publisher\":{\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/europepharmacy.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/#organization\",\"name\":\"European Pharmacy\",\"url\":\"https:\\\/\\\/europepharmacy.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/europepharmacy.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/WhatsApp-Image-2026-09-07-at-18.41.53.jpeg\",\"contentUrl\":\"https:\\\/\\\/europepharmacy.eu\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/WhatsApp-Image-2026-09-07-at-18.41.53.jpeg\",\"width\":1254,\"height\":1254,\"caption\":\"European Pharmacy\"},\"image\":{\"@id\":\"https:\\\/\\\/europepharmacy.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Coke","description":"Coke Hydrochloride analytical standard and Schedule II topical anesthetic reference for forensic testing, clinical pharmacology, and HPLC\/GC-MS assays.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/europepharmacy.eu\/de\/shop\/coke\/","og_locale":"de_DE","og_type":"article","og_title":"Coke","og_description":"Coke Hydrochloride (benzoylmethylecgonine hydrochloride) is an ester local anesthetic and central nervous system stimulant. In clinical medicine, it is an FDA-approved Schedule II topical solution indicated for the induction of local anesthesia and vasoconstriction of accessible mucous membranes during diagnostic and surgical procedures of the nasal cavities and oral mucosa. In analytical chemistry and forensic toxicology, high-purity crystalline standards serve as calibrated benchmarks for quantitative mass spectrometry, presumptive assay validation, and monoamine transporter kinetic profiling. Available strictly by valid prescription or licensed institutional research authorization","og_url":"https:\/\/europepharmacy.eu\/de\/shop\/coke\/","og_site_name":"European Pharmacy","article_modified_time":"2026-09-16T16:33:06+00:00","og_image":[{"width":960,"height":1280,"url":"https:\/\/europepharmacy.eu\/wp-content\/uploads\/2026\/09\/photo_2026-09-16_11-39-18.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Gesch\u00e4tzte Lesezeit":"2\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/europepharmacy.eu\/shop\/coke\/","url":"https:\/\/europepharmacy.eu\/shop\/coke\/","name":"Coke","isPartOf":{"@id":"https:\/\/europepharmacy.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/europepharmacy.eu\/shop\/coke\/#primaryimage"},"image":{"@id":"https:\/\/europepharmacy.eu\/shop\/coke\/#primaryimage"},"thumbnailUrl":"https:\/\/europepharmacy.eu\/wp-content\/uploads\/2026\/09\/photo_2026-09-16_11-39-18.jpg","datePublished":"2026-09-16T09:40:33+00:00","dateModified":"2026-09-16T16:33:06+00:00","description":"Coke Hydrochloride analytical standard and Schedule II topical anesthetic reference for forensic testing, clinical pharmacology, and HPLC\/GC-MS assays.","breadcrumb":{"@id":"https:\/\/europepharmacy.eu\/shop\/coke\/#breadcrumb"},"inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/europepharmacy.eu\/shop\/coke\/"]}]},{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/europepharmacy.eu\/shop\/coke\/#primaryimage","url":"https:\/\/europepharmacy.eu\/wp-content\/uploads\/2026\/09\/photo_2026-09-16_11-39-18.jpg","contentUrl":"https:\/\/europepharmacy.eu\/wp-content\/uploads\/2026\/09\/photo_2026-09-16_11-39-18.jpg","width":960,"height":1280},{"@type":"BreadcrumbList","@id":"https:\/\/europepharmacy.eu\/shop\/coke\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/europepharmacy.eu\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/europepharmacy.eu\/shop\/"},{"@type":"ListItem","position":3,"name":"Coke"}]},{"@type":"WebSite","@id":"https:\/\/europepharmacy.eu\/#website","url":"https:\/\/europepharmacy.eu\/","name":"European Pharmacy","description":"Order Medication &amp; Pills Online","publisher":{"@id":"https:\/\/europepharmacy.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/europepharmacy.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/europepharmacy.eu\/#organization","name":"European Pharmacy","url":"https:\/\/europepharmacy.eu\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/europepharmacy.eu\/#\/schema\/logo\/image\/","url":"https:\/\/europepharmacy.eu\/wp-content\/uploads\/2026\/09\/WhatsApp-Image-2026-09-07-at-18.41.53.jpeg","contentUrl":"https:\/\/europepharmacy.eu\/wp-content\/uploads\/2026\/09\/WhatsApp-Image-2026-09-07-at-18.41.53.jpeg","width":1254,"height":1254,"caption":"European Pharmacy"},"image":{"@id":"https:\/\/europepharmacy.eu\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/product\/10629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/comments?post=10629"}],"version-history":[{"count":2,"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/product\/10629\/revisions"}],"predecessor-version":[{"id":10670,"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/product\/10629\/revisions\/10670"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/media\/10631"}],"wp:attachment":[{"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/media?parent=10629"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/product_brand?post=10629"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/product_cat?post=10629"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/europepharmacy.eu\/de\/wp-json\/wp\/v2\/product_tag?post=10629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}