25 mg Goombah 2C-B

Product Description

2C-B (4-Bromo-2,5-dimethoxyphenethylamine) is a core synthetic substituted phenethylamine combining structural features of mescaline and amphetamine derivatives. In forensic toxicology and chemical profiling, solid compressed tablet matrices featuring regional branding motifs (such as the Netherlands-origin “Goombah” stamp) serve as critical analytical benchmarks. These standards enable forensic chemists to monitor illicit manufacturing trends, quantify active drug loading, evaluate excipient-to-binder ratios, and optimize chromatographic resolution protocols.

Chemical & Pharmacodynamic Properties

• Active Analyte: 4-Bromo-2,5-dimethoxyphenethylamine hydrochloride (25 mg nominal active analyte)

• Molecular Formula & Mass: $\text{C}_{10}\text{H}_{14}\text{BrNO}_2 \cdot \text{HCl}$ | 296.59 g/mol (hydrochloride salt)

• Receptor Mechanism of Action: Operates primarily as a partial agonist with high binding affinity at central serotonin $5\text{-HT}_{2\text{A}}$, $5\text{-HT}_{2\text{B}}$, and $5\text{-HT}_{2\text{C}}$ receptor subtypes. It also exerts secondary modulatory activity at $\alpha$-adrenergic receptors, trace amine-associated receptor 1 ($\text{TAAR}_1$), and vesicular monoamine pathways.

• Forensic Profiling & Solid Matrix Calibration: Standardized compressed matrix facilitates the evaluation of extraction recovery efficiencies, binder interference (e.g., microcrystalline cellulose, magnesium stearate, coloring dyes), and analyte distribution across liquid chromatography-tandem mass spectrometry ($\text{LC-MS/MS}$) and gas chromatography-mass spectrometry ($\text{GC-MS}$) workflows.

• Colorimetric Reagent Spot-Testing: Acts as a reference standard to calibrate presumptive colorimetric transitions:

  • Marquis Reagent: Slowly shifts from clear to light olive green, darkening to deep green/brown.

  • Mecke Reagent: Yields a rapid yellow-to-brownish/green color change.

  • Robadope Reagent: Confirms the presence of a primary amine group through a distinct rose-pink color shift.

Toxicological Risks & Regulatory Compliance

• Forensic and In Vitro Application Only: Synthesized and maintained exclusively for accredited chemical analysis, public health surveillance systems, and forensic reference libraries.

• Toxicological Hazards: Inadvertent in vivo human exposure presents acute clinical risks, including sympathomimetic toxicity (severe tachycardia, hypertension, peripheral vasoconstriction, hyperthermia), sensory distortion, cognitive disorganization, and acute neuropsychiatric panic episodes.

• Legal and Controlled Substance Status: 2C-B is strictly controlled under international law, designated as a Schedule I controlled substance in the United States under the Controlled Substances Act, a Class A drug in the United Kingdom, and listed under Schedule II of the United Nations Convention on Psychotropic Substances. Acquisition, storage, and analysis require valid institutional licensing, secure vault storage, and perpetual inventory tracking.